An abortion clinic worker with a special heritage is enlisted to prevent two angels from reentering Heaven and thus undoing the fabric of the universe. Along the way, she is aided by two prophets, Jay and Silent Bob. With the help of Rufus, the 13th Apostle, they must stop those who stand in their way and prevent the angels from entering Heaven.

This mix of a scripted buddy comedy road movie and a real hidden camera prank show follows the outrageous misadventures of two buds stuck in a rut who embark on a cross-country road trip to NYC. The storyline sets up shocking real pranks.